Anjali was born in Razole, East Godavari District, Andhra Pradesh. She has two brothers and a sister. She completed her schooling in Razole  and later moved to Chennai, Tamil Nadu where she continued her studies, pursuing a degree in Mathematics. After completing her education, she began acting in short films, which paved the way for her entry into the film industry. Anjali remarked that her parents had aspirations to become an actor and that they "realised their dreams" through her.
Anjali is an Indian film actress and model, who predominantly appears in Tamil films. Following a stint in modelling, she was cast in starring roles in two Telugu productions; her début film was the Telugu film Photo, which released in 2006, before bagging a role and gaining attention in the film Kattradhu Thamizh (2007) with Jiiva. In 2010 and 2011, she won the Filmfare Award for Best Actress - Tamil, for her performances in Angaadi Theru and Engaeyum Eppothumrespectively, & Tamil Nadu State Film Award For Angadi Therusubsequently becoming recognised as one of the "finest young actors" in Tamil cinema, and noted for mostly playing "performance-oriented roles".
Her Telugu re-entry occurred through Journey (Telugu dubbing of Engaeyum Eppothum), which established her in Tollywood. Followed by Journey, she appeared in a string of successful films like Seethamma Vakitlo Sirimalle Chettu, Balupu, Masala, Geethanjali and Dictator, which made her one of the leading actresses in Telugu.She also received two Nandi awards for best actress for her performances in the films Seethamma Vakitlo Sirimalle Chettu &Geethanjali. In May 2016,she won Great applauses For her Role in the Tamil Film Iraivi Making Huge Impact on The Tamil Audience's.In August 2017,She appeared in an extended cameo role in director Ram's Taramani (film) Which Earned Good responses from both critics as well as Audience.